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山东省汉族人β_3肾上腺能受体基因多态性分析 被引量:2

β 3 Adrenergic Receptor Gene Polmorphism in Shandong Han Nationality Population
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摘要 应用多聚酶链反应 -限制性片段长度多态性 (PCR- RFL P)技术对 2 12例山东省汉族人 (非糖尿病 80例 ,2型糖尿病 132例 )进行 β3 肾上腺能受体 (β3 AR)基因 Trp6 4 Arg突变分析。结果表明 ,山东汉人β3 AR Trp6 4 Arg等位基因变异频率为 15% ,2型糖尿病组与非糖尿病组β3 AR Trp6 4 Arg基因型和等位基因分布频率无显著差异 (P>0 .0 5)。提示山东省汉族人存在 β3 AR基因变异 。 WT5BZ]212 cases of Shandong Han nationality(80 non-diabetic subjects and 132 patients with type 2 diabetes mellitus) were screened for the detection of the β 3 adrenergic receptor(β 3 AR)gene Trp64Arg mutation by polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) Results showed that about 15 percent of the variant frequency of β 3 AR alleles in this group had been detected and no significant differenec of the gene types and alleles between non diabetic subjects and type 2 diabetic patients had been found It suggests that there exists β 3 AR gene variation in shandong Han nationality But it doesn't closely relate to type 2 diabetes mellitus [WT5HZ]
出处 《山东医药》 CAS 北大核心 2000年第5期5-6,共2页 Shandong Medical Journal
关键词 肾上腺能受体 基因多态性 Ⅱ型糖尿病 β3AR Adrenergic receptor Gene Polymorphism type 2 diabetes mellitus
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参考文献5

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  • 8李明龙,王敏,于桂娜,李茵茵,吕晓霞,赵家军,陈凌.β_3-肾上腺能受体基因Trp64Arg变异与Ⅱ型糖尿病的关系[J].山东医科大学学报,2000,38(1):57-59. 被引量:2
  • 9高从容,邹大进,梅小斌.β_3-肾上腺素能受体基因多态性与2型糖尿病大血管及微血管并发症的关系[J].中华内分泌代谢杂志,2002,18(4):268-269. 被引量:1

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