2010年山东省1～6岁儿童麻疹血清流行病学调查

Sero-epidemiological investigation of measles among children aged 1-6 years old in Shandong Province in 2010

目的了解山东省2010年1～6岁儿童麻疹免疫现状,为免疫策略制定、麻疹预防控制提供借鉴与指导。方法按多级抽样原则,选取烟台、淄博、莱芜、滨州、菏泽5市1～6岁儿童360名开展血清IgG抗体水平检测。结果山东省2010年1～6岁儿童麻疹IgG抗体阳性率均在92.86%以上,东、中、西部地区及1、2,3、4,5、6岁年龄组间抗体阳性率差异均无统计学意义(P>0.05);血清抗体浓度在735.56～2 250.20 U/ml之间,1、2,3、4,5、6和1～6岁年龄组东、中、西部地区抗体浓度差异有统计学意义(F=4.31、6.89、8.97、12.69,均P<0.05)。结论山东省2010年1～6岁儿童麻疹抗体阳性率较高,东部地区抗体浓度明显低于中部及西部地区,需进一步关注。

[Objective]To understand the present situation of measles immunization among children aged 1-6 years old in Shandong Province,provide the reference and guidance for development of immunization strategy and control of measles.[Methods]By stratified sampling,360 children aged 1-6 years old were collected from Yantai City,Zibo City,Laiwu City,Binzhou City and Heze City to detect the serum level of IgG.[Results]In 2010,the positive rates of measles IgG were above 92.86% among children aged 1-6 years old in Shandong Province.There was no significance difference in the positive rate between different districts and different age groups（P0.05）.The serum antibody concentration ranged from 735.56 U/ml-2 250.20 U/ml,and there were significant differences among 1-2 year-old group,3-4 year-old group,5-6 year-old group and 1-6 year-old group（F=4.31,6.89,8.97,12.69,all P0.05）.[Conclusion]The positive rate of measles antibody among children aged 1-6 years old in Shandong Province is high in 2010,and the antibody concentration in east region is lower than that in central region and west region,which should be paid attention to in the future.