肺炎支原体感染治疗研究进展

Research progress on treatment of mycoplasma pneumoniae infection

肺炎支原体(MP)是引起呼吸道感染的常见病原体之一,其病理常呈现毛细支气管炎样改变或间质性肺炎,临床表现以顽固性咳嗽为特征,引起的肺炎和肺外并发症对儿童健康危害较大。MP感染的治疗以抗生素为主,由于不规范用药,耐药菌株不断出现,一些常用治疗MP的抗生素疗效逐渐欠佳。近年来开发的新一代抗生素如大环内酯类、喹喏酮类等疗效好,不良反应少,一些中药方剂治疗MP疗效满意。作者对抗生素的使用、中药治疗等的作用机制及其临床治疗效果作一综述。

Mycoplasma pneumoniae（MP） is one of the common pathogens which cause respiratory infections.Its pathological manifestations often present bronchiolitis-like changes or interstitial pneumonia,its clinical manifestations are characterized by stubborn cough.The induced pneumonia and pulmonary complications possess a great hazard to the health of children.The main MP infection treatment is by antibiotics.But due to non-standard medication,the resistant strains has emerged which results in the gradually poor efficacy of common antibiotics against MP.In recent years,the new generation of antibiotics such as macrolides,quinolones have good efficacy on MP with little adverse effect,as well as several Chinese medicinal formulae.This paper summarizes the use of antibiotics,mechanism and clinical effect of Chinese medicine treatment against MP.