脑梗死再发与危险因素的临床分析

Clinical analysis of recurrent cerebral infarction and its risk factors

目的探讨脑梗死再发患者的临床特点及危险因素,为疾病预防提供依据。方法 112例复发脑梗死患者与136例初发脑梗死患者进行对照研究,比较其临床特点和发病因素。结果初发脑梗死5 a内为再发高峰期,再发脑梗死治疗效果差,致残率高(χ2=5.11,P<0.05)。脑梗死再发者伴高血压、糖尿病者明显多于初发者(χ2值分别为12.51和8.70,均P<0.01),而且血脂和纤维蛋白原水平增高者也明显高于初发者(P<0.01)。结论高血压、糖尿病、高血脂、高纤维蛋白原等都是脑梗死再发的重要危险因素。脑梗死再发高峰期及长期的二级预防应以治疗高血压、糖尿病、高血脂和高纤维蛋白原为主要目标。

[Objective]To study the clinical characteristics and risk factors of patients with recurrent cerebral infarction,provide the basis for disease prevention.[Methods]A control study was conducted between 110 cases of recurrent cerebral infarction and 136 cases of primary cerebral infarction,and the clinical characteristics and risk factors were compared.[Results]The recurrent peak was within 5 years after primary cerebral infarction.The clinical efficacy of recurrent cerebral infarction was not good with higher disability rate（χ2=5.11,P0.05）.The case number of recurrent cerebral infarction complicated with hypertension and diabetes was significantly more than that of primary cerebral infarction（χ2=12.51 and 8.70,both P0.01）.The number of patients with higher levels of blood lipid and fibrinogen in recurrent group was significantly more than that in primary group（P0.01）.[Conclusion]Hypertension,diabetes,hyperlipidemia and higher fibrinogen level are the important risk factors of recurrent cerebral infarction.The recurrent peak prevention and long-term secondary prevention should focus on treating hypertension,diabetes,hyperlipidemia and higher fibrinogen level.