血浆同型半胱氨酸与糖尿病及糖尿病前期的关联研究

Correlation research between plasma homocysteine and diabetes and pre-diabetes

目的探讨血浆同型半胱氨酸（Hcy）与糖尿病及糖尿病前期的相关性。方法共纳入115例确诊为糖尿病的患者以及150例糖耐量异常诊断为糖尿病前期的患者，同时从门诊随机抽取131例无血糖异常的人群作为对照。详细记录所有受试者的基本信息。应用多因素回归分析进行多因素分析。结果糖尿病发生的单因素相关性分析结果显示：高血压病史、高脂血症、体质指数（BMI）≥24kg／m2、高Hcy与糖尿病的发生呈正相关，生活规律与糖尿病的发生呈负相关，差异有统计学意义（P〈0．05或〈0．01）；糖尿病发生的多因素相关性分析结果显示：高血压病史、高脂血症、BMI≥124kg／m2、高Hcy是糖尿病发生的独立危险因素（P〈0．05）。糖尿病前期发生的单因素相关性分析结果显示：高脂血症、BMI≥24kg／m2、高Hcy与糖尿病前期的发生有相关性，差异有统计学意义（P〈0．01）；糖尿病前期发生的多因素相关性分析结果表明：高脂血症、BMI≥24kg／m2、高Hcy是糖尿病前期发生的独立危险因素（P〈0．05）。结论血浆Hcy与糖尿病及糖尿病前期存在密切的相关性，是其发生的独立危险因素。在临床工作中，对高Hcy患者需进行必要的干预。

Objective To discuss the correlation between plasma homocysteine （Hcy） and diabetes and pre-diabetes. Methods Participants included 115 patients with diabetes, 150 patients with abnormal glucose tolerance diagnosis for pre-diabetes and 131 cases without blood glucose abnormalities crowd as control. All the basic informations of the subjects were recorded detailedly. Multiple factors regression analysis was completed. Results Development of diabetes single factor correlation analysis result showed that history of hypertension, hyperlipidemia, body mass index （BMI）≥ 24 kg/m2, high Hcy were positively correlated with development of diabetes, and life rules was negatively correlated with development of diabetes （P〈 0.05 or 〈 0.01 ）. Development of diabetes multiple factors correlation analysis result showed that history of hypertension, hyperlipidemia, BMI ≥ 24 kg/m2, high Hcy were the independent risk factor for development of diabetes （P 〈 0.05）. Development of pre-diabetes single factor correlation analysis result showed that hyperlipidemia,BMI ≥24 kg/m2,high Hcy were correlated with development of pre-diabetes （P 〈 0.01）. Development of pre-diabetes multiple factors correlation analysis result showed that hyperlipidemia, BMI ≥ 24 kg/m2, high Hcy were the independent risk factor for development of pre-diabetes （P 〈 0.05）. Conclusions Plasma Hcy is intimate correlated with diabetes and pre-diabetes, and it is an independent risk factor for development of them. In clinical work, the patients with high Hey need to give the necessary intervention.