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康普瑞丁磷酸二钠壳聚糖-海藻酸钠靶向微球的药代动力学及体内分布研究 被引量:2

Combretastatin A4p pharmacokinetics and in vivo distribution studies of chitosan-sodium alginate targeting microspheres
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摘要 康普瑞丁磷酸二钠(CombretastatinA4p,CA-4P)为新型抗肿瘤前体药物,体内代谢成康普瑞丁活性形式与血管内皮细胞的微管系统结合、阻止新生血管的生成而发挥抗肿瘤的作用,是治疗非小细胞肺癌的药物之一,CA-4P在体内经非特定磷酸酯酶作用可迅速去磷酸化而生成具有生物活性的CA4。
出处 《湖南中医药大学学报》 CAS 2012年第12期13-14,共2页 Journal of Hunan University of Chinese Medicine
关键词 康普瑞丁磷酸二钠 壳聚糖-海藻酸钠靶向微球 药代动力学 组织分布 Combretastatin A4p Chitosan-alginate Microspheres Pharmacokinetics Tissue distribution
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