阿奇霉素缓释微丸体外释药影响因素考察

Factors influencing in vitro release of Azithromycin from Sustained-release pellets

考察影响阿奇霉素缓释微丸体外释药的各种因素,为阿奇霉素缓释制剂的研制提供实验依据。方法选用微晶纤维素为空白丸芯,将阿奇霉素制成缓释微丸,通过测定体外释放度,考察EC粘度及增重、致孔剂用量、释放介质pH值对阿奇霉素缓释微丸体外释药速率的影响。结果 EC粘度、包衣增重、致孔剂用量、释放介质pH值对释药速率有显著影响。结论选用适宜包衣材料及致孔剂,调节包衣增重,可制备具有理想释药行为的阿奇霉素缓释微丸。

OBJECTIVE To investigate the impact of vitro release of Azithromycin sustained-release pellets of various factors,and provide experimental basis for the development of Azithromycin sustained-release formulations.METHODS Selection of microcrystalline cellulose blank pill core made of azithromycin sustained-release pellets,by measuring the in vitro release study EC viscosity,weight gain and pore-forming agents dosage,the release medium pH of in vitro release pill.RESULTS EC viscosity,weight gain,pore-forming agents dosage,the release medium pH had a significant impacts on the release rate.CONCLUSION Selection of suitable coating material and pore-forming agents,adjust coating weight can be used to prepare Azithromycin sustained-release pellets with desired release behavior.