205例地高辛血药浓度测定结果分析

Analysis of 205 cases of blood concentration of Digaoxin

目的对我院2010年1～2012年4月期间常规监测的地高辛血药浓度进行分析,为临床安全、有效、合理使用强心苷类药物提供参考依据。方法采用荧光偏振免疫法测定地高辛血药浓度,对监测的结果进行统计分析。结果在监测的205例使用地高辛的临床病例中,其血药浓度>2.0ng·mL-1的有18例(8.78%),0.8～2.0ng·mL-1的有155例(75.61%),共有15例(7.32%)出现中毒症状,<0.8ng·mL-1的有32例(15.61%)。结论及时监测地高辛血药浓度,对制定个体化给药方案,确保临床疗效,减少毒性反应的发生,具有十分重要的意义。

OBJECTIVE To detect the blood drug level of digoxin in order to offer reference about clinical safety and utility and rational use of cardiac glycoside drugs.METHODS The plama concentration of digoxin was determined by fluorescence polarization immunization,and the monitoring results were subjected to statistical analysis.RESULTS Of the total 205 cases treated with digoxin,the blood drug concentration in 18（8.78%） was above 2.0ng·mL-1,and it was 0.8～2.0ng·mL-1 in 155（75.61%） and less than 0.8ng·mL-1in 32（15.61%）,Toxic symptoms we e noted in 15 cases（7.32%）.CONCLUSION To ensure clinical efficacy and reduce incidence of toxic reactions,it is of great importance to monitior the blood drug level and formulate individual dosage regimen.