长效干扰素与普通干扰素治疗慢性乙肝的成本-效果分析

Cost-effectiveness analysis of peginterferon and common interferon for treatment of chronic hepatitis B

目的研究长效干扰素与普通干扰素治疗慢性乙肝的临床疗效及经济效果。方法选择我院2009年1月至2010年1月收治的慢性乙肝患者100例,随机分成两组,每组各50例,对照组应用普通干扰素治疗,治疗组应用长效干扰素治疗。疗程均为48周,比较这两种方案的临床治疗效果及经济成本。结果对照组的HBV-DNA和HBeAg阴转率分别16%、20%,治疗组的HBV-DNA和HBeAg阴转率分别为68%、76%,两组疗效差异有统计学意义(P<0.05),且治疗组成本效果显著低于对照组。结论长效干扰素治疗慢性乙肝较普通干扰素效果好,且有较好的成本-效果比,值得在临床上推广使用。

OBJECTIVE To study the clinical efficacy and economic effects of peginterferon and common interferon for treatment of chronic hepatitis B.METHODS 100 cases of chronic hepatitis B patients in our hospital from January 2009 to January 2010 were randomly divided into two groups,each group had 50 cases,the control group were given normal interferon therapy,the treatment group were given peginterferon therapy.The treatment lasted 48 weeks,the clinical efficacy and economic costs of these two groups were compared.RESULTS The loss of HBV-DNA and HBeAg in the control group were 16%,20%,respectively,loss of HBV-DNA and HBeAg in the treatment group were 68%,76%,the difference had statistically significant between two groups（P0.05）,and economic costs of the treatment group was significantly lower than the control group.CONCLUSION The effect and cost-effectiveness of peginterferon for treatment of chronic hepatitis B were better than interferon,it is worth to use in clinical practice.