探讨髓过氧化物酶与急性冠状动脉综合征的关系

Relationship between serum level of myeloperoxidase and acute coronary syndrome

目的:探讨血清髓过氧化物酶(MPO)与急性冠状动脉综合征(ACS)的关系。方法:选择我院确诊为急性心肌梗死(AMI)的ACS患者32例(ACS组),采用酶联免疫吸附法分别测定其首诊时及入院后(心肌肌钙蛋白I水平异常升高时)MPO水平,并与健康体检者(38例,正常对照组)作比较。结果:与正常对照组比较,ACS组首诊与入院后MPO水平均显著升高[(85.5±11.5)IU/ml比(101.6±35.5)IU/ml、(95.7±26.1)IU/ml,P<0.05]。结论:血清髓过氧化物酶水平升高可能与急性冠状动脉综合征的发生有关,髓过氧化物酶是一种预测早期急性冠状动脉综合征的炎症标志物。

Objective： To explore relationship between serum level of myeloperoxidase （MPO） and acute coronary syndrome （ACS）.. Methods： A total of 32 ACS patients diagnosed as acute myocardial infarction （AMI） in our hospital were enrolled as ACS group. Enzyme linked immunosorbent assay （ELISA） was used to measure their MPO level during first visit and after admission （cardiac troponin I level abnormally increased）, and their MPO level was compared with that of healthy subjects （n = 38, normal control group） Results： Compared with normal control group, there was significant increase in MPO level [ （85. 5 ± 11.5） IU/ml vs. （101.6 ± 35. 5） IU/ml, （95. 7 ± 26. 1） IU/ml, P〈0. 05] during first visit and after admission in ACS group. Conclusion： Increased serum level of myeloperoxidase may be related with occurrence of acute coronary syndrome. Myeloperoxidase could serve as an inflammatory marker for prediction of early acute coronary syndrome.