冠心病患者超敏C反应蛋白、血脂和尿酸检测的临床意义

Clinical significance of detection of high sensitive C-reactive protein,blood lipids and uric acid in patients with coronary heart disease

目的:探讨监测冠心病(CHD)患者超敏C-反应蛋白(hsCRP)、血脂、尿酸(UA)浓度的意义。方法:选择159例CHD患者(CHD组),其中稳定型心绞痛65例,不稳定型心绞痛48例,急性心肌梗死46例,另选择75例健康体检者作为健康对照组,所有研究对象均进行血清hsCRP、血脂、UA水平检测,并进行比对及分析。结果:与健康对照组比较,CHD组hsCRP[(1.4±0.3)mg/L比(8.5±0.4)mg/L]、TG[(1.8±0.5)mmol/L比(2.4±0.6)mmol/L]、TC[(4.8±0.3)mmol/L比(6.2±0.4)mmol/L]、LDL-C[(2.5±0.7)mmol/L比(6.0±0.2)mmol/L]、载脂蛋白B[ApoB,(0.8±0.2)mmol/L比(2.8±0.9)mmol/L]和UA[(278.5±51.4)μmol/L比(418.6±62.1)μmol/L]水平均明显升高(P<0.05或<0.01);而HDL-C[(2.6±0.3)mmol/L比(1.4±0.4)mmol/L]和Apo A1[(2.8±0.4)mmol/L比(2.2±0.5)mmol/L]水平明显降低(P均<0.01);冠心病各亚组的上述指标与健康对照组比较亦有显著差异(P<0.05～<0.01)。结论:超敏C反应蛋白、血脂和尿酸检测对于冠心病的早期诊断和预后判断具有重要意义。

Objective： To investigate clinical significance of detection of high sensitive C- reactive protein （hsCRP）, blood lipids and uric acid （UA） in patients with coronary heart disease （CHD）. Methods： A total of 159 CHD patients （CHD group） were selected, including 65 cases with stable angina pectoris, 48 cases with unstable angina pectoris and 46 cases with acute myocardial infarction. Another 75 healthy subjects were regard as healthy control group. Serum levels of hsCRP, blood lipids and UA were measured and compared among all groups. Results： Compared with healthy control group, there were significant increase in levels of hsCRP [ （1.4± 0.3） mg/L vs. （8.5 ± 0. 4） mg/L], triglyceride [ （1.8± 0.5） mmol/L vs. （2. 4± 0. 6） mmol/L], total cholesterol [ （4. 8± 0. 3） mmol/L vs. （6. 2 ± 0.4） mmol/L], low density lipoprotein cholesterol [ （2.5 ±0.7） mmol/L vs. （6. 0 ± 0.2） mmol/L], apolipoprotein （Apo） B [ （0.8 ± 0.2） mmol/L vs. （2.8 ± 0.9） mmol/L] and UA [ （278. 5 ± 51.4） umol/L vs. （418. 6 ±62.1） umol/L], P〈0.05 or 〈0.01; and significant decrease in levels of high density lipoprotein cholesterol [ （2.6± 0. 3） mmol/L vs. （1.4 ± 0. 4） mmol/L] and Apo A1 [ （2.8 ± 0.4） mmol/L vs. （2.2 ± 0.5） mmol/L] in CHD group, P〈0.01 both. There were significant difference （P〈0.05 or 〈0.01） on above indexes among all subgroups of CHD and healthy control group. Conclusion： Detection of high sensitive C-reactive protein, blood lipids and uric acid is of important significance for early diagnosis and prognosis judgment of coronary heart disease.