利多卡因与舒芬太尼预处理对丙泊酚注射痛预防作用的比较

Comparison of prophylactic effect of the pretreatment of Lidocaine and Sufentanil on Propofol injection pain

目的探讨预先注射利多卡因与舒芬太尼对丙泊酚注射痛预防作用的区别。方法将ASAⅠ～Ⅱ级拟择期于全身麻醉下行手术的病人150例,随机均分为三组。LP组预先注射利多卡因40 mg后再注射丙泊酚注射液;SP组预先注射舒芬太尼10μg后再注射丙泊酚注射液;CP组为对照组,预先注射同容量的生理盐水后再注射丙泊酚注射液。注射丙泊酚注射液过程中询问疼痛情况,按照不痛、轻度疼痛、中度疼痛、重度疼痛记录疼痛程度。记录各组受试者注射药物前后的SBP、DBP、HR。结果 LP组和SP组病人的丙泊酚注射痛发生率显著低于CP组,差异有显著统计学意义(P<0.01),且LP组的丙泊酚注射痛发生率低于SP组,差异有统计学意义(P<0.05)。结论预先注射利多卡因或舒芬太尼均能有效地抑制丙泊酚注射痛,利多卡因的抑制作用优于舒芬太尼。

Objective To analyze the difference of prophylactic effects of Lidocaine and Sufentanil to Propofol injection pain. Methods 150 patients were classified as ASA Ⅰ～Ⅱ and scheduled to undergo elective surgery under general anesthesia,were randomly assigned into three groups,50 each.Group LP received 2% Lidocaine of 40mg,followed by Propofol injection;Group SP received Sufentanil of 10μg,followed by Propofol injection;Group CP was the placebo control group and received Propofol injection after administered with normal saline of 2ml as the placebo.The pain situations were enquired during Propofol injection and recorded the levels according to the no pain,mild pain,moderate pain and severe pain.SBP,DBP and HR before and after injection were recorded. Results The incidences of Propofol injection pain in group LP and SP were significantly lower than that in group CP,the difference has statistical significance（P0.01）,and the incidence of injection pain in group LP was lower than that in group SP with a significant difference（P0.05）. Conclusion The pretreatment of Lidocaine and Sufentanil has effective prophylactic effects on the Propofol injection pain and Lidocaine has the better prophylactic effect on injection pain over Sufentanil.