尿微量白蛋白在早期肾损害中的诊断价值

Value of urinary microalbumin in diagnosis of early renal damage

目的探讨尿微量白蛋白在早期肾损害中的诊断价值。方法对本院155例尿常规蛋白均为阴性的糖尿病和高血压患者采用免疫比浊法检测尿微量白蛋白水平,并同时用酶法检测血清肌酐与尿素水平,并进行统计分析。结果 155例尿常规蛋白为阴性的糖尿病和高血压患者中,有尿微量白蛋白异常者80例。其中101例糖尿病患者中55例异常[mAlb=(56.2±32.5)mg/L],为54.5%。54例高血压患者中25例异常[mAlb=(51.3±33.4)mg/L],为46.5%。明显高于其正常范围(mAlb<20 mg/L)。而同时检测的血肌酐与尿素,101例糖尿病患者中12例异常,为11.9%;54例高血压患者中3例异常,为5.6%。结论尿微量白蛋白的检测,在糖尿病肾病早期及高血压的诊治中有重要的临床意义。

Objective To Discuss the value of urinary microalbumin in diagnosis of early renal damage. Methods One hundred and fifty-five patients with diabetes and hypertension who were diagnosed with negative urine protein in our hospital were received urinary microalbumin examination by turbidimetric immunoassay,serum creatinine and urea levels were detected by enzymic method.The results were statistical analyzed. Results There were 80 cases of abnormal urinary microalbumin in 155 negative urine protein patients with diabetes and hypertension.Among 101 cases of diabetes,55 cases were abnormal [mAlb=（56.2±32.5）mg/L],accounting for 54.5%.25 cases were abnormal in 54 cases of hypertension [mAlb=（51.3±33.4）mg/L],accounting for 46.5%,significantly higher than theirs normal range（mAlb20 mg/L）.While the results of serum creatinine and urea levels examination showed that there were 12 abnormal cases in 101 patients with diabetes,accounting for 11.9%;3 cases were abnormal in 54 cases of hypertension,accounting for 5.6%. Conclusion Detection of urinary microalbumin has important clinical signifi-cance in the diagnosis and treatment of early stage diabetic nephropathy and hypertension.