普洱茶对apoE基因敲除小鼠血脂的影响

Effects of Pu-er Tea on Blood Lipid of apoE-gene Knocked Mice

[目的]为了验证普洱茶对apoE基因敲除小鼠动脉粥样硬化的作用。[方法]选取55只4周龄雄性apoE基因敲除小鼠,按照体重随机分成正常对照组、降脂药组、模型组、生茶组、熟茶组共5组,用普洱茶汤进行干预性试验90 d后,空腹12 h,摘眼球采血,采用全自动生化仪测血清中的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)等血脂指标。[结果]普洱茶(生、熟)均可显著控制小鼠体重增长(P<0.05);普洱生茶可显著降低小鼠血清中TG、LDL-H含量,升高HDL-C含量(P<0.05),可显著降低AI系数(P<0.05)。[结论]普洱茶对apoE基因敲除小鼠的抗动脉粥样硬化有一定的调节作用。

[ Objective] To verify the effects of Pu-er tea on the anti-atherosclerosis in the apoE-gene knocked mice. [ Method] 55 4-weeks male apoE-gene knocked mice were randomly divided into fiver groups according to weight （normal control group, lipid lowering drug group, model group, fresh tea, cooked tea）. After 90 days, limosis for 12 h, TC, TG, LDC-G and HDL-C were detected with full automatic bio- chemical analyzer. [ Result] Pu-er tea can significantly control increase of body weight （P 〈 0.05 ） ; Pu-erh tea can significantly reduce TG, LDL-H content, increase HDL-C content （ P 〈 O. 05）, as well as AI coefficient. [ Conclusion] Pu-er tea has regulation function on anti-ather- osclerosis of apoE-genc knocked mice.