蝮蛇抗栓酶治疗肾综合征出血热的临床研究

CLINICAL STUDY OF THE APPLICATION OF AHYLYSANTINFARCTASE IN THE TREATMENT OF HFRS

目的 探讨治疗肾综合征出血热 ( HFRS)的有效方法及疗效。方法 将 2 0 2例 HFRS住院病人 ,随机分为治疗组 1 0 2例 ,对照组 1 0 0例。两组均按病期采用以抗病毒、平衡盐液为主的对症综合治疗 ;治疗组加用蝮蛇抗栓酶 0 .5u,加入 5%葡萄糖 2 50 ml中静脉滴注 ,1次 /d,直至多尿期后2～ 3d停药。结果 治疗组在退热、恢复肾功能、尿蛋白阴转、血小板恢复正常时间及越期率等方面均优于对照组 ( P <0 .0 1 )。结论 蝮蛇抗栓酶治疗 HFRS具有改善肾微循环 ,促进肾功能恢复 ,预防和治疗弥散性血管内凝血 ( DIC)的作用。

Objective To explore an effective therapy for the treatment of hemorrhagic fevere of renal syndrome (HFRS).Methods 202 inpatients with HFRS were divided into two groups,i.e.102 cases in the treatment group and 100 in the control group.Both groups were treated with anti virus drugs and balanced salt solution,while the treatment group was injected with 0.5 unit of Ahylysantinfarctase in 250ml of glucose solution(5%) in addition each day,2 or 3 more days after the polyuria stage started.Results Better curative effects were obtained in the treatment group than in the control group in the abatement of fever,the restoration of renal functions,urinary protein and blood platelets.Conclusion Ahylysantinfarctase can be applied in the treatment of HFRS to improve the microcirculation,accelerate the recovery of renal functions and to prevent disseminated intravascular coagulation DIC.