E系统和HBV母婴传播相关关系的Meta分析

Meta-analysis of role of hepatitis B e antigen and anti HBe antibody in HBV mother-to-infant transmission

目的 探讨 E系统在 HBV母婴传播中的作用 .方法 运用 Meta分析技术对 18个 HBV母婴传播研究进行定量综合分析 .结果 母亲 E抗原阳性具有高度危险性 (OR=2 4.6 7,95 % CI:13.17～ 46 .0 6 ) ,E抗体阳性则相对不显著(OR=1.2 0 ,95 % CI:0 .5 5～ 2 .5 8) ,对各研究结果作齐性检验 ,无显著差异 (P>0 .0 5 ) .结论 E抗原阳性是

AIM To explore the role of HBeAg and anti HBe in the mother to infant transmission of HBV. METHODS Meta analysis was used to evaluate the data extracted from 14 published papers in order to make formal summary statements about the relation between HBeAg/anti HBe positive mothers and their infants. RESULTS A summary odds ratio(OR) of HBV infection in infants of 24.67 (95% CI 13.17～46.06) for HBeAg positive compared with HBeAg negative mothers and of 1.20 (95% CI 0.55～2.58) for anti HBe positive compared with anti HBe negative mothers was obtained. CONCLUSION HBeAg plays a definite role in mother to infant transmission of HBV.