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肿瘤坏死因子-α基因-238位点单核苷酸多态性与Infliximab治疗类风湿性关节炎疗效的相关性 被引量：4

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摘要 目的探讨肿瘤坏死因子-α(TNF-α)基因-238位点基因单核苷酸多态性(SNP)与Infliximab(英夫利昔单抗)治疗类风湿性关节炎(RA)疗效的相关性。方法对102例中国RA患者使用Infliximab进行治疗,以28处关节疾病活动度评分(DAS28)、健康评估问卷(HAQ)评分及美国风湿病学会(ACR)与欧洲抗风湿病联盟(EULAR)共同制定的RA临床缓解新标准为工具,评估Infliximab对RA的疗效。采用TaqMan MGB探针法检测TNF-α基因-238位点的SNP。统计分析TNF-α基因-238位点的SNP与Infliximab治疗RA疗效的相关性。结果具有GG基因型的RA患者在治疗后DAS28评分和HAQ评分均显著降低(P<0.05),而具有AA基因型及AG基因型的RA患者在治疗后DAS28评分和HAQ评分均无显著变化(P>0.05)。具有GG基因型的RA患者在治疗后达到临床缓解新标准的比例为91.8%,显著高于非GG基因型的RA患者。除有2例RA患者因对Inflix-imab过敏而退出试验外,未见结核、肿瘤发生等严重不良反应。结论 TNF-α基因-238位点的SNP与Inflix-imab治疗RA疗效可能相关,具有GG基因型的RA患者对Infliximab的疗效反应较好,而具有AA基因型及AG基因型的RA患者疗效反应则相对较差。
作者 李博 胡秋侠 钟贵芳 何伟珍 孔卫红 陈雅硕 谢燕 李剑松 张丽君 叶志中
机构地区 广东省深圳市第四人民医院香蜜湖风湿病分院风湿科 广东省深圳市福田区中医院急诊科 广东省深圳市第四人民医院肛肠分院消化内科门诊
出处 《广东医学》 CAS CSCD 北大核心 2012年第24期3741-3744,共4页 Guangdong Medical Journal
基金 广东省深圳市医学重点学科建设基金资助项目(编号:2005C10) 广东省深圳市科技计划项目(医疗卫生类)(编号:200903207)
关键词 肿瘤坏死因子-Α 单核苷酸多态性 INFLIXIMAB 类风湿关节炎
分类号 R574.62 [医药卫生—消化系统]
  • 相关文献

参考文献16

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共引文献38

同被引文献102

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引证文献4

二级引证文献20

广东医学
2012年 第24期

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