多系统器官衰竭患者血清—氧化氮测定及临床意义

Serum nitric oxide measurement and clinical significance in patients with multiple system organ failure

目的研究一氧化氮 (NO)与多系统器官衰竭 (MSOF)发病及预后的关系。方法采用Griess法测定 5 2例MSOF患者 ,131例单一器官衰竭 (SOF)患者和 2 3例正常人血清NO水平。结果MSOF患者血清NO水平较正常对照组显著升高 (P <0 0 5 ) ;SOF患者中 ,心衰组、呼衰组、肝衰组和胃肠衰竭组血清NO水平较正常对照组显著升高 (P <0 0 0 1,P <0 0 1,P <0 0 5 ,P <0 0 0 1) ,而肾衰组、血液系统衰竭组和中枢神经系统衰竭组血清NO水平较正常对照组显著降低 (P <0 0 0 1,P <0 0 1,P<0 0 0 1) ;MSOF患者血清NO水平较SOF患者显著升高 (P <0 0 5 ) ;随器官衰竭数目增多 ,NO水平有升高趋势 ,但相互间比较差异无意义 (P >0 0 5 ) ;MSOF患者死亡组的NO水平较生存组显著升高 (P<0 0 1)。结论NO是反映MSOF病情及评价预后的一项重要参考指标。

Objective To study the correlation between morbidity and prognosis in serum nitric oxide(NO) with Multiple System Organ Failure (MSOF). Methods The levels of serum NO in 52 patients with MOSF, 131 patients with Single Organ Failure (SOF) and 23 normal controls were detected by the Griess method. Results The serum NO levels in patients with MOSF were markedly higher than the normal controls ( P <0.05); among the single organ failure cases that heart failure group,respiratory failure group, hepatic failure group and gastrointestinal failure group of the serum NO levels were markedly higher than the normal control ( P <0.001, P <0.01, P <0.05, P <0.001). But renal failure group,hematological system failure group and central nervous system failure group of the serum NO levels were obviously lower than the normal controls ( P <0.001, P <0.01, P <0.001). The serum NO levels were markedly higher in the MSOF than the SOF ( P <0.05). NO levels of the serum tend to rise as the number of organs failure increased. The serum NO levels of MSOF patients were markedly higher in the death group than the survival group. Conclusion No play important role in judging of the disease occurrence and development.