老年下呼吸道感染病原菌的分布及药敏试验

Drug sensitive test and observation on changes of pathogenic bacteria of senile lowerrespiratory tract infection (LRTI)

目的探讨 1992年 1月至 1997年 12月住院的老年下呼吸道感染患者的病原菌分布、耐药情况 ,供临床用药借鉴。方法对痰中分离的细菌进行分类、鉴定 ,并对其中的不动杆菌进行药敏试验。结果 6年的病原菌分布已发生改变 ,虽然仍以革兰氏阴性杆菌为主 ,且肠杆菌仍居首位 ,但不动杆菌和其它非发酵菌呈逐年上升趋势。用 12种抗生素 ,对钙不动杆菌的药敏结果表示 ,钙不动杆菌耐药率较高 ,但对氧哌嗪青霉素、复达欣、氧氟沙星及氨基甙类的抗生素 ,仍保持较好的敏感性 ,敏感率为 5 5 2～ 86 8%。结论虽然病原菌发生变迁 ,耐药情况严重 ,但仍有敏感的抗生素可选用。

Objective The distribution and drug resistance of pathogenic bacteria of senile patients with LRTI admitted to hospital between January 1992 to December 1997 were studied for clinical medication guidance. Methods Bacteria from the patients' sputum were classified and determined, furthermore, amotile bacilli were used for drug sensitive test. Results The pathogenic bacteria distribution had varied since 1992, which mainly were Gram negative bacilli and enterobacteria, however, the trend of gradual increase of amotile bacilli and a eymotic bacilli was also evident. The results of drug sensitive test of calcium amotile bacilli to 12 kinds of antibiotics indicated that calcium amotile bacilli, although with higher drug resistance rate, were still well-sensitive to antibiotics such as Fortum and Tarividetd with sensitive rate 55.2%-86.6%. Conclusion Some kinds of antibiotics can still be used clinically.