摘要
Purpose: To analyze the prevalence of HLA-B27 associated acute anterior uveitis and to identify its clinical features. Methods: A total of 240 patients with HLA-B27 associated acute anterior uveitis,who were admitted to Zhejiang Ophthalmologic Hospital between December 2006 and October 2012, were retrospectively analyzed.The age of onset,sex,affected eyes,HLA-B27 antigen detection,recurrence,joint involvement, and surgical complications were investigated. Results:The average age of onset was 37.0 ±12.0 years and the ratio of male to female patients was 2.4:1. Most cases had alternate unilateral or bilateral involvement. Among all participants, 234 cases (97.5%) were HLA-B27 positive, and 124 cases (51.7%) had spondyloarthropathies (SpA), dominated by 108 cases with ankylosing spondylitis. (AS,45.0%),and mostly seen in male subjects(P<0.05).Six patients were HLA-B27 negative(2.5%)and on statistical significance was noted between male and female patients (P >0.05).A total of 193 cases (80.4%) presented with complications, mainly fibrinous exudation, posterior synechia, and vitreous opacity. Conclusion: HLA-B27 that is associated acute anterior uveitis with a relatively high incidence and recurrence presents with more severe clinical features than does idiopathic acute anterior uveitis,and it often accompanies systemic arthritic diseases. HLA-B27 antibody detection is associated with the diagnosis and treatment of acute anterior uveitis.
Purpose： To analyze the prevalence of HLA-B27 associated acute anterior uveitis and to identify its clinical features. Methods： A total of 240 patients with HLA-B27 associated acute anterior uveitis, who were admitted to Zhejiang Ophthal- mologic Hospital between December 2006 and October 2012, were retrospectively analyzed. The age of onset, sex, affected eyes, HLA-B27 antigen detection, recurrence, joint involvement, and surgical complications were investigated. Results： The average age of onset was 37.0±12.0 years and the ratio of male to female patients was 2.4：1. Most cases had alternate unilateral or bilateral involvement. Among all participants, 234 cases （97.5%） were HLA-B27 positive, and 124 cases （51.7%） had spondyloarthropathies （SPA）, dominated by 108 cases with ankylosing spondylitis （AS,45.0%）, and mostly seen in male subjects（P〈0.05）. Six patients were HLA- B27 negative （2.5%） and on statistical significance was noted between male and female patients （P〉0.05）. A total of 193 cases （80.4%） presented with complications, mainly fibrinous exudation, posterior synechia, and vitreous opacity. Conclusion： HLA-B27 that is associated acute anterior uveitis with a relatively high incidence and recurrence presents with more severe clinical features than does idiopathic acute anterior uveitis, and it often accompanies systemic arthritic diseases. HLA-B27 antibody detection is associated with the diagnosis and treatment of acute anterior uveitis.
基金
study of UBM monitoringsystem in the diagnosis and treatment of anterior uveitis (NO.Y20090284)
granted by Science and Technology Bureau of Wenzhou,China
