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DNA甲基转移酶抑制剂在动物体细胞核移植研究中的应用 被引量：1

Application of DNA Methyltransferase Inhibitors in Animal Somatic Cell Nuclear Transfer Research
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摘要 甲基化对胚胎发育和机体形成具有重要的调控作用,体细胞核移植胚胎常常表现出异常的DNA甲基化,DNA甲基转移酶抑制剂能抑制细胞的DNA甲基化水平,从而达到提高体细胞核移植效率的作用。作者主要综述了DNA甲基转移酶抑制剂在动物体细胞核移植研究中的应用。 Methylation plays an important regulatory role in embryo development and organization.Somatic nuclear transfer embryos often show the abnormal mode of DNA methylation,DNA methyltransferase inhibitors can inhibit the levels of DNA methylation,so as to improve the efficiency of SCNT.The application of DNA methyltransferase inhibitors in animal somatic cell nuclear transfer was taken an overview in this paper.
作者 蒙丽娜 罗婷 柯浩 刘晓华 孙洪亮 陆凤花 石德顺
机构地区 广西大学亚热带农业生物资源保护与利用国家重点实验室
出处 《中国畜牧兽医》 CAS 北大核心 2012年第12期133-136,共4页 China Animal Husbandry & Veterinary Medicine
基金 国家"863"项目(2011AA100607) 国家自然科学基金项目(31072033) 教育部高等学校博士学科点博导基金项目(20114501110001) 广西杰青项目(2012GXNSFFA060004) 广西科学基金项目(2010GXNSFF013002) 广西优秀人才资助计划(2010-1-1)
关键词 DNA甲基化 DNA甲基转移酶抑制剂 体细胞核移植 DNA methylation DNA methyltransferase inhibitors somatic cell nuclear transfer
分类号 Q345.21 [生物学—遗传学]
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参考文献24

  • 1李凤珍,易建明.DNA甲基化酶抑制剂对体细胞染色体的影响[J].中国畜牧兽医,2009,36(9):63-67. 被引量：1
  • 2姜蕊,宋伟.RG108对肺腺癌A549细胞增殖、凋亡及RASSF1A基因表达的影响[J].中国组织化学与细胞化学杂志,2009,18(4):354-358. 被引量：3
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二级参考文献14

  • 1Bureau W S, Bordignon V, Leveillee C, et al. Assessment of chromosomal abnormalities in bovine nuclear transfer embryos and in their donor cells [J]. Cloning Stem Cells, 2003,5(2) :123 -132.
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中国畜牧兽医
2012年 第12期

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