血细胞分析仪网织红细胞测定在化疗患者中的应用

Blood cell analyzer reticulocyte determination in chemotherapy patients

目的：探讨恶性肿瘤患者化疗前后网织红细胞的变化及其临床价值。方法：采用全自动血红胞分析仪检测50例患者化疗前后外周血网织红细胞及白细胞的变化。结果：化疗后第3天开始网织红细胞进行性下降（P〈0．01），到第10天降至最低，第14天开始上升；而白细胞到第14天时降到最低．第21天恢复至化疗前水平（P〉0．05）；RET〉0．3的患者发生III°～IV°骨髓抑制的概率远低于RET≤0．3的化疗患者（P〈O．01）。结论：网织红细胞度其参数的变化可以更敏感的反应骨髓的造血功能，可作为化疗患者监测骨髓功能的重要指标。

Objective： To investigate the variation of reticulocytes in malignant tumor patients before and after chemotherapy its clinical significance. Methods：The reticulocytes and leukocytes were examined by blood analyzer using the peripheral blood of 50 malignant tumor patients before and after chemotherapy. Result： On the 3rd day after chemotherapy, the reticulocytes decreased aignificantly gradual]y（P〈0.01）,on 10th day it to a minimum, then 14th began to rise. On the 14th day after chemotherapy, the leukocytes to a minimum, the 21st recovery before chemotherapy（F〉 0.05）. Of RET〉0. 3 in patients with III°-IV°bone marrow suppression, much lower than the probability of RET≤0.3 patients treated with chemotherapy（P〈0.01）. Conclusion：The reticulated and its parameters level can be used as the more responsive bone marrow hematopoietic function and be used as an important indicator of the chemotherapy patients to monitor bone marrow function.