HELF联合化疗治疗晚期胃癌临床研究

CIinical Study of HELF Combined Chemotherapy for PatientsWith Advanced Gastric Carcinoma

目的 观察羟基喜树硷 (HCPT) ,足乙叉甙 (VP 16 ) ,甲酰四氢叶酸钙 (LV)加 5一氟脲嘧啶 (5 Fu)组成HELF联合化疗方案对晚期胃癌的疗效。方法自 1993年 4月至 1997年 2月 ,用HELF方案治疗 52例晚期胃癌 ,具体用药 :HCPT8mg m2 divd1～ 5;VP - 16 6 0mg m2 divd1～ 5;LV10 0mg m2 divd1～ 5;5-FU6 0 0mg m2 divd1～ 5。结果 52例病人中达完全缓解的有 4例 (CR7 6 9% ) ;部分缓解 2 5例 (PR4 8 0 7% ) ;总有效率 (CR +PR)是 55 76 % ,其有效率高于对照组ELF方案 4 1 16 % (P <0 0 5)。中位生存期 10个月也优于对照组 7 5个月 (P <0 0 5)。

Objective To study the effect of patients with advanced gstric carcinoma was systemic combined chemotherapy with ELF reginen,consisting of 10 hrdroxycmptothecine(HCPT),etoposide(Vp 16),Leucovorin(LV)and 5 fluorouracil(5 Fu).Methods From Apr 1993 to Fed.1997,52 cases of advanced gastric carcinoma were treated with HELF combined chemotherapy,i.e HCPT8mg/m 2/div; ;VP 16 60mg/m 2/d iv;LV 100mg/m 2/d iv and 5-FU600mg/m 2/d iv,all drugs for 5 days cycles were repeated for every 28 days.Results Four patients achieved a complete response (CR7 67%),twenty five patients had a partial response (PR48 07%),thus RR (CR+RR) was 55 76%.The RR rate was higher than ElF regimen in our control group(41 16%)( P <0 05).HELF! s longer than ELF in the mean time of servival( P <0 05).HELF combined chemotherapy produced mild and transient hemeologic toxicity,the most common toxicities were gastrointestinal reaction and alopecia.Nausea vomiting can be prevented:by 5 HT3 antireceptor drug.Conclusion HELF regimen provides new favorable and safe tretment for patients with advanced gastric carcinoma.