进化化学——利用达尔文进化论发明与改良功能生物大分子,及其在药物研制中的应用

Evolutionary chemistry——inventing and improving functional biomacromolecules by harnessing Darwinian evolution; and its application in drug research and development

进化化学作为化学和生物学的交叉学科 ,系在实验室中应用达尔文进化论 ,通过定向分子进化来发明与改良功能生物大分子 ;可用于获得接头、催化性多聚核酸、催化抗体等功能性生物大分子。该文综述了这一领域的主要进展及其在药物研究与开发 (如先导化合物的发现和新型诊断与治疗方法的设计 )中的应用。

Evolutionary chemistry was proposed as a new field at the crossroads of chemistry and biology in which functional bio macromolecules such as aptamers, catalytic polynucleotides, and catalytic antibodies were invented and improved via directed molecular evolution by harnessing Darwinian evolution in laboratory. Progress in the field is briefly reviewed and possible application of evolutionary chemistry in drug research and development such as discovery of lead compounds and design of new diagnosis and therapeutic method is also reviewed. [