拓扑异构酶Ⅱ在胃癌中的表达

Significance of Topoisomerase Ⅱ in Primary Gastric Carcinomas

目的 探讨胃癌拓扑异构酶 与 ki- 6 7表达的相关性。 方法 免疫组织化学方法研究 2 76例原发性胃癌拓扑异构酶 和 ki- 6 7标记指数的变化关系。 结果 弥漫型胃癌拓扑异构酶 和 ki- 6 7的标记指数明显高于肠型胃癌 ,拓扑异构酶 标记指数与 ki- 6 7标记指数呈明显的正相关 (r=0 .5 334 ,P<0 .0 5 ) ,但 ki- 6 7标记指数明显高于拓扑异构酶 的标记指数。 结论 拓扑异构酶 标记指数除可作为肿瘤患者抗药性指标外 ,还可作为肿瘤细胞增殖指数的指标 ,拓扑异构酶

Objective\ Purpose to study the relationship between label index of topoisomerase Ⅱ and ki\|67.\ Methods\ By using immunohistochemical method, the significance of the expression of topoisomerase Ⅱ and ki\|67 were investigated in the primary gastric carcinomas.\ Results\ The label index of topoisomerase Ⅱ and ki\|67 in diffuse\|type carcinomas were higher than those in intestinal\|type carcinomas.\ There was significant correlation between the label index of topoisomerase Ⅱ and ki\|67(r=0 5334,P<0 05), but the label index of ki\|67 was higher than those of topoisomerase Ⅱ. \ Conclusion\ These findings suggest that topoisomerase Ⅱ not only serve as the index of the multidrug resistance, but also as the index of cellular proliferation.\ The expressive contents of topoisomerase Ⅱ is associated with malignant transformation.\;