大叶马蹄香根中的黄酮类成分

Studies on flavonoids from the root of Asarum maximum

研究大叶马蹄香 (AsarummaximumHemsl.)根中的化学成分。方法 :用溶剂提取、色谱法分离大叶马蹄香的化学成分 ,并用理化常数和波谱法鉴定其结构。结果 :从大叶马蹄香根的乙醇提取物中分离到 5个黄酮类成分 ,根据理化性质和波谱数据鉴定其结构分别为柚皮素 (Ⅰ ) ,柚皮素 5 O β D 吡喃葡萄糖苷 (Ⅱ ) ,柚皮素 5 ,7 O β D 2吡喃葡萄糖苷 (Ⅲ ) ,4,2′,4′,6′ 四羟基查耳酮 2′ ,4′ 二 O β D 吡喃葡萄糖苷 (IV)和 4,2′ ,4′ ,6′ 四羟基查耳酮 2′ O β D 吡喃葡萄糖苷 (V)。 结论 :上述化合物均为首次从该植物中获得 ,其中化合物Ⅱ ,Ⅳ ,Ⅴ为首次从细辛属植物中获得。

Objective: To study the constituents of the root of Asarum maximum Hemsl. Methods: The constituents were extracted and separated by various chromatographies , and the structures were identified on the basis of their chemical and physical properties and spectral analysis. Results: Five flavonoids were isolated from the ethanol extract of the roots of Asarum maximum , and their structures were identified as naringenin (Ⅰ), naringenin 5 O β D glucopyranoside (Ⅱ), naringenin 5,7 di O β D glucopyranoside (Ⅲ), 4,2′,4′,6′ tetrahydroxy chalcone 2′,4′ di O β D glucopyranoside (Ⅳ) and 4,2′,4′,6′ tetrahydroxy chalcone 2′ O β D glucopyranoside (Ⅴ). Conclusion: All of these compounds were separated for the first time from this plant and compounds Ⅱ, Ⅳ and Ⅴ from the genus Asarum .