广西2005～2011年高发出生缺陷变化趋势分析

Analysis of Trend in Prevalence of Major Birth Defects in Guangxi from 2005 to 2011

目的了解广西高发出生缺陷发生率及其变化情况,为采取干预措施提供依据。方法按照国家出生缺陷监测方案,对2005～2011年广西壮族自治区围产儿进行出生缺陷监测,统计分析高发出生缺陷的发生率、类别。结果广西高发出生缺陷依次为先天性心脏病(26.82/万)、胎儿水肿综合征(24.51/万)、多指(趾)(22.06/万)、总唇裂(15.46/万)、外耳其他畸形(11.10/万)。2005～2011年先天性心脏病发生率呈上升趋势(P<0.01),胎儿水肿综合征发生率呈下降趋势(P<0.01)。结论应对高发出生缺陷进行相关病因研究,采取干预措施,以降低出生缺陷的发生率。

Objective To investigate the prevalence of major birth defects and its change trend in Guangxi,so as to provide a basis for adopting interventions. Methods According to National Birth Defect Monitoring Program, all perinatal infants in Guangxi from 2005 to 2011 were investigated and statistically analyzed for prevalence and categories of major birth defects. Results The first five common deformities in Guangxi were as follows ： congenital heart disease （26.82/10 000） ,fetal edema syndrome （24.51/10 000 ）, polydactyly （22.06/10 000）, cleft lip （15.46/10 000 ） and external ear malformation（11. 10/10 000）. From 2005 to 2011 ,there was an ascending trend in the prevalence of congenital heart disease（P 〈0.01 ） ,and a descending trend in the prevalence of fetal edema syndrome（P 〈0.01 ）. Conclusion Study on related factors of major birth defects and adopting interventions should be done ,so as to effectively reduce the prevalence of birth defects.