摘要
为阐明口服补锌对利福平致肝损害的影响 ,采用利福平 ip 50 mg· kg-1· d-1,连续 2 1 d,造成大鼠肝损害模型 .同时口服硫酸锌液 ,每只大鼠 1 .2mg·d-1连续 2 1 d.结果发现单独给予利福平可使大鼠血清和肝脏中脂质过氧化产物及血清谷丙转氨酶水平升高 ,病理学检查也发现明显肝损害 .同时补锌则可拮抗利福平所致大鼠血清和肝脏中脂质过氧化产物及血清谷丙转氨酶水平升高 ,提高肝脏金属硫蛋白水平 ,肝脏病理学检查也有明显改善 .提示锌对利福平致肝损害有一定预防作用 .
To investigate the protective effect of zinc sulfate on the rifampicin(RFP)-induced hepatic injury, the rats were given RFP 50 mg·kg -1·d -1 ip for 21 d, meanwhile zinc 1.2 mg·kg -1·d -1 po was given. The results indicated that RFP increased the malondialdehyde(MDA) content both in the serum and in the liver of rats, and enhanced the activity of glutamic-pyruvic transaminase (GPT) and total bilirubin content in the serum of rats. Histologically, significant degeneration and necrosis were observed in the hepatic tissues. Zinc decreased the elevation of MDA content, GPT activity and total bilirubin content induced by RFP. Histological exam also proved the preventive effect of zinc. The liver metallothionein(MT) level in zinc treated rats was also increased. The data suggest that zinc has preventive effect on the RFP-induced hepatic injury. Restraining the liquid peroxidation and inducing MT synthesis may be responsible in its preventive effect.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2000年第3期222-226,共5页
Chinese Journal of Pharmacology and Toxicology
关键词
利福平
肝损害
硫酸锌
预防
rifampicin
zinc
hepatic injury
metallothionein
glutamic-pyruvic transaminase
