耄塞通治疗便秘的药效学及急性毒性观察

Observe on the Pharmic Effect and Acute Toxicity of Maosaitong (耄塞通)on the Management of Constipation

目的 :观察耄塞通对大、小鼠胃肠运动功能的影响。方法 :采用大、小鼠灌胃给药的方法 ,观察 3组实验动物 2 4h排便情况、粪便中水分含量、胃肠推进功能及对大小鼠的急性毒性作用。结果 :耄塞通组动物排便量、稀粪数及稀便占总粪便的百分数、粪便中水分含量均较空白对照组显著增加 ( P<0 .0 5 ) ,对胃肠道推进运动有促进作用。结论 :耄塞通能使大便在肠道中停留的时间缩短 ,水分吸收减少 ,排便量增加 。

Objective:To observe the effect of Maosaitong(MST) on constipation.Method:Defecating in 24h,water content in stool,advance function of stomach and intestines and acute toxicity of drugs in three groups of experimental animals(small mice) were observed.Result:The stool,watery stool and water in stool in MST group were higher than the control group.The difference between two groups was significant(P<0.05).Conclusion:MST can shorten the time of stool in large intestine and lower the water absorbing in intestines,so experimental research provide the treatment theory foundation of MST