破格救心汤治疗慢性心力衰竭大鼠的实验研究

Experimental Study of Poge Jiuxin Decoction in the Treatment of Heart Failure Rat Models

目的:研究破格救心汤治疗慢性心力衰竭(CHF)模型大鼠的有效性、安全性和作用机制。方法:实验分为空白组、模型组和破格救心汤组。记录各组大鼠一般情况和死亡情况,并检测各组大鼠的心电图、心脏系数和血小板膜糖蛋白ⅡbⅢa(GP-ⅡbⅢa)浓度。结果:与模型组比较,破格救心汤组大鼠心衰表现明显好转;模型组死亡率33.3%,破格救心汤组和空白组无死亡。与模型组比较,破格救心汤组大鼠心电图S-T段回落,T波变缓,差异明显;心脏系数无明显差异(P>0.05);GP-ⅡbⅢa浓度降低(P<0.01)。结论:破格救心汤治疗心衰大鼠有效,使用相对安全,这可能与附子、山萸肉、麝香等的强心作用及其对GP-ⅡbⅢa浓度的调节有关。

This study was aimed to evaluate the effectiveness, safety and mechanism of action of Poge Jiuxin decoction in the treatment of heart failure in rat model. The experiment animals were divided into the blank control group, model group and Poge Jiuxin decoction group. The general condition and mortality were recorded in each group. The electrocardiogram cardiac index and platelet membrane glycoprotein ⅡbⅢa concentration were detected among rats from each group. The results showed that compared with model group, Poge Jiuxin decoction group significantly performed better in the treatment of heart failure rats. The mortality rate of model group was 33.3%. And there was no death in the Poge Jiuxin decoction group and the blank control group. Compared with the model group, the electrocardiogram of Poge Jiuxin decoction group showed S-T segment drop and slow T wave. There was significant difference. There was no significant difference on the cardiac index （P 〉 0.05）. And the GP-ⅡbⅢa concentrations was lower （P 〈 0.01）. It was concluded that Poge Jiuxin decoction were effective in the treatment of heart failure rats. It is relatively safe. It may relate to the eardiotonic action and GP-ⅡbⅢa concentrations regulation by aconite root, dogwood, musk and etc.