国产丙氧咪唑驱猪蛔虫的药效试验

Trials on drug efficacy of resistance to Ascaris suum infection by home-made Oxibendazole

为评价国产丙氧咪唑驱猪蛔虫的效果,我们将90头自然感染猪蛔虫的仔猪,分成丙氧咪唑3个治疗剂量组和药物、空白对照各1组(平均每组18头),进行药效试验.丙氧咪唑的3个组,分别以国产丙氧咪唑15、10、5毫克/公斤剂量顿服.10天后,虫卵阴转率依次为94.44%、94.44和27.78%,减卵率依次为99.55%,99.54%和86.30%;药物对照组以噻嘧啶10毫克/公斤剂量顿服.10天后,虫卵阴转率为61.11%;空白对照组不用药物,10天后虫卵阳性率为100%.结果表明,国产丙氧咪唑是驱猪蛔虫的有效药物,疗效较好,服药后也未发现严重的不良反应.

Oxibendazole was given to 18, 18 and18 patients with Ascaris suuminfection in a single dosage of 15, 10 and 5 mg/kg respectively, 10 days post-treat-ment, the egg negative conversion rates of A. suum were 94.44, 94.44 and 27.78% r-espectively, the egg redaction rates of A. suum were 99.55, 99.54 and 86.36% respec-tively. other 18 cases of A. suum infection treated with Pyrantel in 10 mg/kg, the eggnegative conversion rate was 61.11%, after 10 days, and yet the egg positive ratein the control group was 100%. No marked adverse reactions were observed by cl-inical and laboratory examinations. The preliminary results indicated that thehome-made Oxibendazole is highly effective in resistance to A. suum, infe-ction.