热性惊厥患儿血浆和脑脊液β-内啡肽的变化

Changes of plasma and cerebrospinal fluid β-endorphin children with febrile convulsion

目的：探讨β－内啡肽在小儿热性惊厥中临床意义。方法：用放射免疫法检测２８例热性惊厥和１５例对照组患儿血浆和脑脊液中的卜内啡肽含量。结果：热性惊厥组患儿血浆和脑脊液中β－内啡肽水平显著高于对照组（Ｐ＜０．０１）；且复杂性热性惊厥患儿脑脊液中β－内啡肽含量显著高于单纯性热性惊厥患儿（Ｐ＜０．０５）。热性惊厥组患儿的血浆与脑脊液的β－内唯肽水平呈明显正相关。结论：β－内啡肽在小儿热性惊厥的发病中可能起重要作用。

Objective: To elucidate the the of β-endorphin (β-EP) in children with febrile convulsion. Methods: Plasma and cerebrospinal fluid (CSF) β-EP level of 28 cases of febrile convulsion (FC) were measured with radioimmunoassay and compared to 15 cases of healthy controls. Results: Plasma and CSF β-EP of FC group were significantly higher than those of controls. In the group of complicated febrile convulsion, β-EP level of CSF were markedly higher than those of simple febrile convulsion group. The level of plasma β-EP had positive correlation with CSF β-EP in FC group. Conclusion: β-EP may play an important pathophysiologic role in children with febrile convulsion.