生长抑素受体在胆囊癌组织的表达及临床意义

Expression of Somatostatin Receptors in Gallbladder Cancer and its Significance

目的探讨生长抑素受体亚型蛋白在胆囊癌组织中的表达、发生发展中的作用及其相关性。方法对病理确诊的29例胆囊癌组织标本采用免疫组化法检测生长抑素受体亚型的表达。分析生长抑素受体亚型的表达与淋巴结转移、分化程度及预后的关系。结果 SSTR 5种亚型在胆囊癌组织均有表达,SSTR表达的优势是SSTR3;SSTR3在中高分化胆囊癌中的表达明显高于低分化胆囊癌(P<0.05);SSTR4在有淋巴结转移的胆囊癌的表达低于无淋巴结转移者(P<0.05)。经统计学分析,5种SSTR亚型表达情况均与患者年龄、肿瘤组织学类型、浸润深度、肝脏转移无明显相关性。结论胆囊癌组织及正常胆囊黏膜均表达5种SSTR亚型,优势表达是SSTR3;SSTR3及SSTR4的表达胆囊癌的恶性程度有关,提示这两种SSTR亚型表达可能在胆囊癌发展过程中发挥重要作用。

Objective To study the role of somatostatin receptor（SSTR） subtypes 1 - 5 in the process of genesis development of gallbladder cancer and their relationship. Methods Immunohistochemical staining was used to examine the expressions of SSTR1 - 5 in 29 cases of gallbladder cancer specimens. Results SSTR 5 subtypes in gallbladder cancer tissues were expressed, and the advantages expression was the SSTR3. The expression of SSTR3 in well-differentiated gallbladder carcinoma was signifi- cantly higher than poorly differentiated gallbladder carcinoma （ P 〈 0.05 ） ;The expression of SSTR4 with lymph node metastasis of gallbladder cancer was lower than that without lymph node metastasis（ P 〈 0.05 ）. The expression of 5 SSTR subtype were not as- sociated with patient age, tumor histological type, depth of invasion and liver metastasis. Conclusion Gallbladder cancers and normal gallbladder mucosa all expressed SSTR 5 subtypes protein, and the advantage expression was SSTR3;SSTR3 and SSTR4 was correlated with malignant degree of gallbladder cancer and may play an important role in the progression of gallbladder canc- er