儿童支气管哮喘患者血清IL-8、IL-4和IL-9检测的临床分析

Clinic analysis of serum interleukin-8,4 and 9 levels of the children with bronchial asthma

目的研究白细胞介素-8(IL-8)、白细胞介素-4(IL-4)和白细胞介素-9(IL-9)在儿童支气管哮喘气道炎症中的作用。方法将186例支气管哮喘患儿采用常规基础治疗,总疗程6个月,应用化学发光免疫进行血清IL-8、IL-4和IL-9水平测定。另选40名健康儿童作为对照。结果支气管哮喘患儿治疗前血清IL-8、IL-4和IL-9含量均明显高于正常对照组(P<0.05)。治疗后患儿血清IL-8、IL-4和IL-9含量均下降,与治疗前比较差异均有统计学意义(P<0.05),与正常对照组相比差异无统计学意义(P>0.05)。结论 IL-8、IL-4和IL-9参与儿童支气管哮喘患者气道炎症过程,血清IL-8、IL-4和IL-9含量可作为儿童支气管哮喘患者病情变化及疗效判定的参考指标之一。

Objective To observe the effects of serum interleukin-8, 4, 9 on the bronchial asthma airway inflammation in children. Methods 186 cases of children with bronchus asthma in our hospital during 2010 May to 2010 December were randomly selected, and given routine clinical therapy for 6 months, and observed the levels of the serum interleukin-8, 4, and 9 before and after treatment using chemiluminescence immunoassay （CLIA）, and compared with that in normal children. Results Before the treatment, the levels of the serum interleukin-8, 4, and 9 in the children with bronchus asthma were all higher than those in the normal. While after the treatment, the levels were all significantly decreased. Conclusion IL-8, IL-4 and IL-9 all participate in the process of the children bronchus asthma airway inflammation. The levels of serum interleukin-8, 4, and 9 can be a good kind of reference index of disease prognosis and treatment efficacy determination in the children with bronchus asthma.