盐酸氨基葡萄糖结合塞来昔布治疗膝骨关节炎的疗效观察

Evaluation of Glucosamine Hydrochloride Combined with Celecoxib in the Treatment of Knee Osteoarthritis

目的观察评价盐酸氨基葡萄糖结合塞来昔布治疗膝骨关节炎(KOA)的疗效及安全性。方法 2001年3月-2012年3月采用随机对照方法,将184例KOA患者随机分为对照组与试验组,各92例。对照组单独给予塞来昔布,试验组给予塞来昔布和盐酸氨基葡萄糖,共治疗8周,停药后继续观察4周。采用Lequesne指数作为疗效评分标准,观察服药前后的膝关节症状变化,包括休息痛、运动痛、压痛、肿胀、晨僵和行走能力的改善程度,纪录不良反应及实验室生化指标等。结果两组Lequesne指数在治疗前相比均明显下降,两组治疗8周后Lequesne总指数比较差异均有统计学意义(P<0.05)。治疗8周后试验组总有效率明显优于对照组。安全性方面两组比较无差异。结论盐酸氨基葡萄糖结合塞来昔布治疗KOA,能明显改善患者的临床症状,疗效优于单纯的塞来昔布治疗,且不会增加药物不良反应,具有较好的临床价值。

Objective To observe and evaluate the efficacy and safety of combined therapy of glucosamine hydrochloride and celecoxib in the treatment of knee osteoarthritis（KOA）.Methods A randomized,controlled clinical trial was performed.A total of 184 patients suffering from early and metaphase knee osteoarthritis were divided into control group and experimental group randomly.Patients in the control group were treated with celecoxib,and those in the experimental group were treated with both celecoxib and glucosamine hydrochloride,respectively,for 8 weeks.Knee pain at rest,at movement and at pressure,knee swelling,morning stiffness and walking ability were recorded according to Lequesne index.Other features such as therapeutic efficacy,adverse events and laboratory parameters were also recorded.Results The Lequesne scores of the experimental group in eight weeks after treatment were significantly different from the control group（P0.05）.The symptomatic improvement rates of the experimental group eight weeks after treatment were much higher than those in the control group.There was no significant safety difference between the two groups.Conclusions The combined therapy of glucosamine hydrochloride and celecoxib on knee osteoarthritis can significantly improve the clinical symptoms.It is more effective than celecoxib alone without increasing the side effects.