“5.12”地震应激对灾区人群消化道疾病相关激素水平的影响

The Impacts of "5.12" Earthquake Stress on Victims' Gastrointestinal Hormone Levels

目的探讨地震应激对胃泌素、生长抑素、血清超氧化物歧化酶(SOD)活性和丙二醛(MDA)水平的影响,为震后灾区人群应激性溃疡的防治提供理论依据。方法随机抽取四川省人民医院2008年5月15日-31日间收治的60名5.12汶川地震灾民为研究组,58名健康体检者作为对照组。分别对两组人群进行心理调查,采用酶联免疫吸附法测定血清胃泌素和生长抑素水平,利用生化法检测血清SOD活性和MDA含量,并对上述各指标在两组间的分布进行比较。结果研究组症状自评量表得分高于对照组(P<0.05);两组血清胃泌素分别为(1.04±0.67)、(0.74±0.58)ng/mL,研究组高于对照组(P<0.01);两组MDA水平分别为(7.16±5.58)、(4.83±4.48)nmol/mL,研究组高于对照组(P<0.05);而两组生长抑素分别为(0.74±0.94)、(1.92±3.05)ng/mL,研究组低于对照组(P<0.01);两组SOD分别为(6.06±2.20)、(7.79±1.58)U/mL,研究组低于对照组(P<0.01)。结论地震可引起生理应激状态,导致机体在免疫、抗氧化能力、胃肠激素等方面出现一系列变化,胃泌素、生长抑素等均参与应激性疾病的形成,这些变化可能导致地震灾区消化性溃疡高发。

Objective To investigate the impact of earthquake stress on victims＇ gastrointestinal hormone levels,including gastrin,somatostatin,superoxide dismutase（SOD） and malon dialdehyde（MDA）,in order to provide a theoretical base for the prevention and treatment of earthquake stress ulcer.Methods We randomly chose 60 earthquake victims treated between May 15 to 31,2008 to be included in the study group and another 58 healthy individuals were included in the control group.The mental status of subjects in both two groups was investigated with self-rating anxiety scale and self-rating depression scale.The serum levels of gastrin and somatostatin were determined by enzyme-linked immunosorbent assay,and levels of SOD and MDA were determined by biochemical methods.And the differences in above indicators between the two groups were studied.Results The SCL-90 score of the study group was higher than that of the control group（P0.05）.The levels of gastrin（1.04 ± 0.67 and 0.74 ± 0.58,P0.01） and MDA（7.16 ± 5.58 and 4.83 ± 4.48,P0.05） of the study group were significantly higher than those of the control group.However,the levels of somatostatin（0.74 ± 0.94 and 1.92 ± 3.05,P0.01） and SOD（6.06±2.20 and 7.79±1.58,P0.01） of the study group were lower than those of the control group.Conclusion As a strong stress,earthquake can inhibit the immunological function and produce changes in emotional state,and gastroenterological hormones,etc,and these changes may produce the elevation of stress ulcer morbidity after earthquake.