摘要
目的观察5-氟尿嘧啶节律性化疗对晚期胃癌患者的临床疗效。方法选择我院24例晚期胃癌患者,使用5-氟尿嘧啶500 mg静脉持续泵入12 h d1-21,4周1个疗程,3～9个疗程后,对接受至少3个疗程的患者进行疗效评价。结果 24例患者随访8～24个月,3例部分缓解(12.5%),9例病情稳定(37.5%),无1例患者完全缓解,12例患者病情进展(50.0%),疾病控制率为50.0%。治疗有效患者的中位疾病进展时间(TTP)为3.2个月。结论 5-氟尿嘧啶节律性化疗可以有效控制老年晚期胃癌患者的病情进展,不良反应少且轻。
Objective To observe the clinical efficacy of 5-fluorouracil rhythm chemotherapy treating on patients with advanced gastric cancer.Methods Choose 24 patients with advanced gastric cancer in our hospital,intravenous continuous infusion 5-fluorouracil 500 mg 12 h d1-21,4 weeks treatment as a course,3~9 courses later,evaluate the clinical efficacy of patients who were received at least 3 courses.Results 24 patients followed up for 8~24 months,3 patients partial remission（12.5%）,9 patients stable condition（37.5%）,there was no patients complete remission,the rest 12 patients continue to progress（50%）,disease control rate was 50%.The median time of progression of the effective treatment patients was 3.2 months.Conclusion 5-fluorouracil rhythm chemotherapy could effective control patients with advanced gastric cancer,adverse reactions are few and mild;Disease control rate.
出处
《胃肠病学和肝病学杂志》
CAS
2012年第12期1119-1121,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
5-氟尿嘧啶
节律性化疗
胃癌
临床疗效
疾病控制率
5-fluorouracil
Rhythm chemotherapy
Gastric cancer
Clinical efficacy
Disease control rate
