孔结构渐变聚己内酯/羟基磷灰石仿生骨材料

Bionics materials of hydroxyapatie/poly(ε-caprolactone) with gradual change pore structure

为获得具有类似人骨的渐变孔结构、力学性能良好的羟基磷灰石(hydroxyapatite,HA)/聚己内酯(polycaprolactone,PCL)仿生骨材料,采用水热法制备了HA粉末,通过溶剂共混法将其与PCL复合,并采用浇铸/NaCl微粒浸出法制备了多孔状HA/PCL复合材料.通过控制造孔剂NaCl的粒径和用量得到了不同孔径、不同孔隙率的HA/PCL复合材料及具有渐变孔结构的HA/PCL复合材料.利用光学显微镜观察了其孔结构,结果为孔径在100～300μm,最大孔隙率达到80%.同时研究了它们在人体体温附近(37±5)℃的力学性能,结果表明渐变孔结构的HA/PCL复合材料的力学性能较单一孔结构的HA/PCL复合材料有了很大的提高.通过梯度造孔不仅可获得与人骨极为类似的多孔仿生材料,同时还可大幅提高多孔材料的力学性能.

To get hydroxyapatite（HA）/ polycaprolactone（PCL） bionic bone material with gradual changing pore structure similar to the bone structure and good mechanical properties,HA powder was prepared by hydrothermally synthesized method,and it had been compounded with PCL via solvent blending method,then vesicular HA/PCL composite were prepared with cast/sodium chloride particle-leaching technique.On this basis,HA/PCL composite with different pore size,different porosity rate and HA/PCL composite with gradual changing pore structure were achieved via changing the particle size and the quantity of sodium chloride.The pore structures were observed by optical microscope,and the pore size is from 100~300 μm,the maximum porosity rate is of 80%.What＇s more,the mechanical properties had been studied near the body temperature（37±5） ℃,and the results indicated that the mechanical properties were greatly improved compared to the HA / PCL composite with single pore structure.