血清胎盘生长因子与冠状动脉侧支循环的关系

Relationship between serum placental growth factor and coronary collateral circulation

目的探讨冠状动脉粥样硬化性心脏病(以下简称冠心病,CHD)患者血清胎盘生长因子(placental growth factor,PlGF)浓度与冠状动脉侧支形成的关系。方法根据冠状动脉造影结果入选78例冠状动脉严重狭窄的CHD患者,按Rentrop方法进行冠状动脉侧支分级:0级(23例),1级(23例),2级(18例),3级(14例),采用酶联免疫法检测患者血清PlGF浓度。结果冠状动脉侧支为0级、1级患者的PlGF血清水平均明显低于冠状动脉侧支为2、3级组患者(P<0.01);冠状动脉侧支分级与PlGF血清水平呈明显正相关(r=0.534,P<0.01)。结论在严重的CHD患者中,PlGF血清浓度与冠状动脉侧支分级呈明显正相关,提示PlGF可能有促进冠状动脉侧支循环形成的作用。

Objective To investigate the relation between serum placental growth factor（PlGF） level and coronary collateral circulation（CCC） in patients with coronary artery disease.Methods A total of 78 patients with coronary artery disease（CAD） with severe coronary stenosis were included according to coronary angiography,CCC severities were divided into the following 4 degrees： degree 0（n=23）,degree 1（n=23）,degree 2（n=18）,degree 3（n=14） by Rentrop method.Serum concentration of PlGF was measured by enzyme-linked immunosorbent assay（ELISA）.Results Serum PlGF level in patients with CCC degree 0 and 1 was decreased as compared with that in CCC degree 2 and 3（P〈0.01）.The CCC degrees had a significant positive correlation with serum levels of PlGF（r=0.534,P0.01）.Conclusion In severe coronary artery disease,serum concentration of PlGF showed a significant positive correlation with coronary collateral circulation,suggesting that PlGF may be a factor that can enhance coronary collateral circulation.