期刊文献+

SOX2在成年小鼠室周器官细胞的表达及其意义 被引量:7

Significance of SOX2 protein expression in cells of circumventricular organs in adult mouse
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摘要 目的:检测成年小鼠SOX2在成年小鼠室周器官细胞和脑室下区细胞的表达及其差异。方法:成年BALB/c雄性小鼠,免疫组织化学检测SOX2在室周器官细胞的表达。结果:SOX2在最后区(AP)、正中隆起(ME)、穹隆下器(SFO)、联合下器(SCO)和脉络丛细胞均有强表达,与脑室下区SOX2阳性细胞比较,除SCO外,均有差异。结论:在成年小鼠室周器官分布有大量的SOX2阳性细胞,表明成年小鼠室周器官可能存在具有增殖和分化潜能的神经干细胞/祖细胞。 Objective: To observe the expression and difference of SOX2 positve cells in the adult mouse circumventicular or gans (CVOs) and subventricular zone. Methods: SOX2 positive cells 0f adult male mice were detected by immunohistochem ical staining. Results: The SOX2 positive cells were densely found in area postrema (AP), median eminence (ME), subfor nical organ (SFO), subcommissural organ (SCO), choroid plexus and subventricular zone. Except SCO, the percentages of postive cells were different between CVOs and subventricular zone. Conclusion: Ahundent SOX2 positive cells are found in CVOs of adult mice that suggest the existence of neural stem/progenitor cells, which can proliferate and differentiate into new neurons and/or glia.
出处 《解剖学杂志》 CAS CSCD 北大核心 2012年第6期758-760,795,共4页 Chinese Journal of Anatomy
基金 河北省卫生厅医学科学研究重点资助课题(20100032)
关键词 SOX2 神经干细胞 祖细胞 小鼠 室周器官 SOX2 neural stem/progenitor cell mice circumventricular organs
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参考文献21

  • 1Pevny L, Placzek M. SOX genes and neural progenitor identity [J]. Curr Opin Neurobiol, 2005,15(1) : 7-13.
  • 2German& A, Montalbano G, Guerrera M C, et al. Developmental changes in the expression of sox2 in the zebrafish brain [J]. Mi crosc Res Tech, 2010,74(4) :347-354.
  • 3Ellis P, Fagan B M, Magness S T, et al. SOX2, a persistent marker for multipotential neural stem cells derived from embryon- ic stem cells, the embryo or the adult [J]. Dev Neurosci, 2004, 26 (2-4) : 148-165.
  • 4Johansson C B, Momma S, Clarke D L, et al. Identification of a neural stem cell in the adult mammalian central nervous system [J]. Cell, 1999,96(1):25-34.
  • 5Hendriekson M L, Rao A J, Demerdash O N, et al. Expression of nestin by neural cells in the adult rat and human brain [J]. PloS One, 2011,6(4) :e18535.
  • 6Foret A, Quertainmont R, Botman O, et al. Stem cells in the a dult rat spinal cord: plasticity a{ter injury and treadmill training exercise [J]. J Neurochem, 2010,112(3) :762-772.
  • 7马常升,曹翠丽.脑室周围器官解剖学[M].北京:科学出版社,2009.
  • 8郝庆卯,张祥宏,邢凌霄,王俊灵,严霞,马常升,王丽,刘贵生,王凤荣,杨天祝.杂色曲霉素对小鼠穹窿下器室管膜细胞超微结构的影响[J].解剖学杂志,2005,28(6):650-652. 被引量:7
  • 9Ferri A L, Cavallaro M, Braida D, et al. Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain [J]. Development, 2004,131(15) :3805-3819.
  • 10Mackay-Sim A. Stem cells and their niche in the adult olfactory mucosa [J]. Arch Ital Biol, 2010,148(2) : 47-58.

二级参考文献16

  • 1McKinley MJ,McAllen RM,Davern P,et al.The sensory circumventricular organs of the mammalian brain.Adv Anat Embryol Cell Biol,2003,1729(3):111-122.
  • 2Plata-Salaman CR.Immunoregulators in the nervous system.Neurosci Biobehav Rev,1991,15(2):185-215.
  • 3Quan N,Stern EL,Whiteside MB,et al.Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat.J Neuroimmunol,1999,93 (1-2):72-80.
  • 4Sunn N,McKinley MJ,Oldfield BJ.Circulating angiotensin Ⅱ activates neurons in circumventricular organs of the lamina terminalis that project to the bed nucleus of the stria terminalis.J Neuroendocrinol,2003,15 (8):725-731.
  • 5Tanaka J,Mashiko N,Kawakami A,et al.GABAergic systems in the nucleus tractus solitarius regulate noradrenaline release in the subfornical organ area in the rat.Auton Neurosci,2002,100(1-2):58-65.
  • 6Grinevich V,Harbuz M,Ma XM,et al.Hypothalamic pituitary adrenal axis and immune responses to endotoxin in rats with chronic adjuvant-induced arthritis.Exp Neurol,2002,178 ( 1 ):112-123.
  • 7Krout KE,Kawano J,Mettenleiter TC,et al.CNS inputs to the suprachiasmatic nucleus of the rat.Neuroscience,2002,110(1):73-92.
  • 8Xia Y,Krukoff TL.Cardiovascular responses to subseptic doses of endotoxin contribute to differential neuronal activation in rat brain.Brain Res Mol Brain Res,2001,89 (1-2) :71-85.
  • 9Harre EM,Roth J,Pehl U,etal.Selected contribution:role of IL-6 in LPS-induced nuclear STAT3 transloeation in sensory circumventricular organs during fever in rats.J Appl Physiol,2002,92(6) :2657-2666.
  • 10曹文军,王会艳,张祥宏,孙旭明,谢同欣,严霞,王俊灵,王凤荣.杂色曲霉素致人胚肺细胞p53及Ki-ras基因突变研究[J].卫生研究,2000,29(3):175-177. 被引量:13

共引文献13

同被引文献124

  • 1郝庆卯,秦永,李力,李岳,叶建亚,李波,曹翠丽,马常升.Nestin/SOX2及SOX2/BrdU在成年小鼠室周器官细胞的表达[J].解剖学杂志,2014,0(3):315-319. 被引量:1
  • 2郝庆卯,张祥宏,邢凌霄,王俊灵,严霞,马常升,王丽,刘贵生,王凤荣,杨天祝.杂色曲霉素对小鼠穹窿下器室管膜细胞超微结构的影响[J].解剖学杂志,2005,28(6):650-652. 被引量:7
  • 3崔卫刚,郭灵,邓祥发,魔洁琳.Ⅰ型糖尿病脑病大鼠学习记忆及侧脑室室管膜下区神经发生的变化[J].四川解剖学杂志,2006,14(3):7-9. 被引量:10
  • 4马常升,曹翠丽.脑室周围器官解剖学[M].北京:科学出版社,2009.
  • 5Bennett L, Yang M, Enikolopov G, et al. Circumventricular or- gans: a novel site of neural stem cells in the adult brain [ J ]. Mol Cell Neurosci, 2009, 41:337 - 347.
  • 6Huang SL, Shi W, Jiao Q, et al. Change of neural stem ceils in the ehoroid plexuses of developing rat [ J ]. Int J Neurosci, 2011, 121 : 310 -315.
  • 7Johnson AK, Gross PM. Sensory circumventricular organs and brain homeostatic pathways [J]. FASEB J, 1993, 7:678 -686.
  • 8Moyse E, Bauer S, Chattier C, et aL Neurogenesis and neural stem ceils in the dorsal vagal complex of adult rat brain : New vistas about autonomic regulations-a review[ J]. Auton Neurosci, 2006, 126 - 127:50 - 58.
  • 9Cameron HA, McKay RD. Adult neurogenesis produces a large pool of new granule ceils in the dentate gyrus [ J ]. J Comp Neurol, 2001,435:406 -417.
  • 10Bennett L B, Cai J, Enikolopov G, et al. Heterotopically transplan- ted CVO neural stem ceils generate neurons and migrate with SVZ cells in the adult mouse brain[ J ]. Neurosci Lett, 2010, 475:1 - 6.

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