左旋氨氯地平治疗老年原发性高血压

Levorotatory amlodipine in treatment of elderly primary hypertension

目的分析左旋氨氯地平治疗老年原发性高血压的临床特点。方法选择老年原发性高血压患者112例，随机分为两组，观察组56例患者给予苯磺酸左旋氨氯地平治疗，对照组56例患者给予苯磺酸氨氯地平治疗，比较两种药物治疗的临床特点、效果及安全性。结果治疗前两组患者血压比较差异无统计学意义，治疗4周、8周后两组收缩压与舒张压均明显下降，治疗前后比较差异有统计学意义，观察组治疗效果好于对照组，两组比较差异有统计学意义（P〈0．05）。观察组不良反应率为3．57％，对照组不良反应率为10．71％，两组比较差异有统计学意义（P〈0．05）。结论左旋氨氯地平治疗老年原发性高血压效果显著，且不良反应明显减少，患者耐受性好。更适合于老年患者服用。

Objective To analyse the clinical characteristics of levorotatory amlodipine in treat- ment of elderly primary hypertension. Methods Choose 112 elderly patients with essential hypertension and randomly divided into two groups. The observation group （56 cases ） were given benzene sulfonic acid levorotatory amlodipine. The treatment group （56 cases） were given benzene sulfonic acid amlodip- ine treatment. Compared the clinical characteristics, effect and safety of the two groups. Results There was no significant difference of the blood pressure between the two groups before treatment. Four and eight weeks after treatment, SBP and DBP dropped significantly after treatment in both groups compared with before treatment. The efficacy of observation group was better than that in the control group, and the difference was significant（ P 〈 0.05 ）. The adverse reaction rate of observation group was 3.57%, and the control group was 10. 71%, the difference between the two groups was statistical significant（ P 〈 0. 05 ）. Conclusions The efficacy of levorotatory amlodipine in treatment of elderly primary hyperten- sion is significant, and it can obviously reduce adverse reactions, patients with good tolerance and is more suitable for elderly patients.