紫草油配合微波热疗防治急性放射性皮肤损伤的临床疗效

Clinical effects of Lithospermum oil combined with microwave diathermy in prevention and treatment of acute radiation-induced skin injury

目的观察紫草油配合微波热疗在急性放射性皮肤损伤防治中的疗效。方法将120例接受放射治疗的恶性肿瘤患者随机分为对照组(n=60)和治疗组(n=60)。对照组患者接受常规宣教及临床常规护理。治疗组患者在照射野皮肤上涂抹紫草油,每日3次,直至放疗结束2周后;当超过Ⅱ级皮肤损伤发生时,配合微波热疗,隔日1次,温度设为38～40℃;其常规宣教及临床常规护理同对照组。结果治疗组患者急性放射性皮肤损伤的总发生率为85.0%,对照组为100.0%;治疗组患者急性放射性皮肤损伤的程度比对照组轻,无Ⅳ级皮肤损伤发生,且发生皮肤损伤的时间推迟。与对照组比较,治疗组患者创面疼痛明显减轻(P<0.05);皮肤愈合时间明显缩短(P<0.05)。结论紫草油配合微波热疗可降低急性放射性皮肤损伤,缩短皮肤愈合时间。

Objective To observe the clinical effects of Lithospermum oil combined with microwave diathermy in prevention and treatment of acute radiation induced skin injury. Methods 120 patients with malignancy who accepted radiotherapy were randomly divided into the control group（n=60） and the treatment group（n=60）. Patients in the control group received conventional propa ganda and education,and routine clinical nursing. Patients in the treatment group were subjected to smearing the skin in radiation treatment field with Lithospermum oil thrice a day until two weeks after the end of radiotherapy, and microwave diathermy every other day with temperature set to 38--40 C when grade I1 skin injury occurred. Meanwhile,conventional propaganda and routine clinical nursing were conducted as those in the control group. Results The overall incidence of acute radiation-induced skin injury in the treatment group was 85.0% and the control group 100%. The degree of acute radiation-induced skin injury of patients in the treatment group was lower than that in the control group, with no grade IV skin injury found and delayed occurrence of skin damage. Compared with patients in the control group,wound related pain was markedly reduced （P〈0.05） and skin healing time was obviously shorten（P〈0.05） in the treatment group. Conclusion Lithospermum oil combined with microwave diathermy can reduce acute radiation-induced skin injury and shorten the skin healing time.