参麦注射液与氨茶碱治疗膈肌疲劳的临床对照研究

Clinical Controlled Study of Shenmai Injection and Aminophylline on Diaphragm Fatigue

目的：探讨参麦注射液、氨茶碱治疗慢性阻塞性肺病（ＣＯＰＤ）患者呼吸衰竭时隔肌疲劳效果的异同性。方法：６４例ＣＯＰＤ伴呼吸衰竭和膈肌疲劳的住院患者，随机分为参麦注射液组（简称参麦组）和氨茶碱组，两组在抗感染、吸氧等综合治疗基础上分别加用参麦注射液和氨茶碱静脉滴注，观察膈肌疲劳消失的起效时间、２４ｈ维持有效率及治疗前后动脉血气的变化。结果：３０ｍｉｎ内有效率及２４ｈ维持有效率参麦组分别为７５．７６％、３９．３９％，氨茶碱组分别为５１．６１％、３．２３％，参麦组疗效优于氨茶碱组（Ｐ＜０．０５， Ｐ＜０．０１）；两组均能提高氧分压（Ｐ＜０．０１），降低二氧化碳分压（Ｐ＜０．０１），两组比较无显著性差异。结论：参麦注射液治疗ＣＯＰＤ患者呼吸衰竭时隔肌疲劳的疗效明显优于氨茶碱。

To compare the therapeutic effect of Shenmai injection (SM) and aminophylline (AP) on diaphragm fatigue in chronic obstructive pulmonary disease (COPD). Methods: Sixty-four COPD patients with respiratory failure and diaphragm fatigue were randomly divided into 2 groups: (1) SM group (33 patients), treated with oxygen inhalation and anti-infection agents, and SM injection (SM 40 ml + 10 % glucose 100ml), (2) AP injection group (31 patients), treated with AP 0. 25 g plus 10 % glucose 100 ml, and the same comprehensive treatment, To investigate the initial time of diaphragm fatigue disappearance, the maintaining effect of 24 hours of drug administration, and the arterial blood gas analysis. Results: The effect in 30 min and maintaining effect in 24 hours in SM group were better than those in the AP group. In both groups, PaO2 increased and PaCO2 decreased. Conclusion: The therapeutic effect of SM on COPD patients with respiratory failure and diaphragm fatigue was better than those of AP.