冬虫夏草菌粉对尖锐湿疣Th1/Th2免疫应答的调节

Effect of Cordyceps sinensis on the Th 1/Th 2 Cytokines in Patients with Condyloma Acuminatum

目的:探讨冬虫夏草菌粉对尖锐湿疣(CA)患者体内IL-2及IL-10水平的影响,及预防电灼术后CA复发的作用;方法:采用ELISA双抗体夹心法对34例冬虫夏草治疗组患者和29例对照组患者治疗前后血清中IL-2及IL-10含量检测,观察常规电灼术后CA复发情况;结果:经冬虫夏草治疗2月后CA患者血清IL-2水平明显较前升高(P<0.05),IL-10水平降低(P<0.01)。而对照组IL-2及IL-10水平变化不甚明显(P>0.05)。电灼术后治疗组复发次数显著低于对照组(P<0.05),复发率(41.2％)亦低于对照组(65.5％)。结论:冬虫夏草菌粉可能通过对机体Th 1/Th 2亚群失衡进行调整,增强 CA患者 Th l介导的细胞免疫功能达到抗病毒、减少复发的作用。

Objective: To investigate the effect of cordyceps sinensis ( CS) on the Th 1 /Th 2 cytokines and recurrence in patients with Condyloma Acuminatum (CA). Method: Double-antibody sandwich ELISA was used lo study the serum level of Il-2 and IL-10 in 34 patients treated with CS (CS group) and 29 patients in control group. The recurrence rate of CA was observed. Result: After treated with CS, the serum levels of IL-2 and IL-10 significantly increased and decreased respectively (P < 0.05 or 0,01). No significant change occurred in control group. The recurrence times of CA in patients of CS group after electrocauteri-zation were significantly lower than control group (P<0.05). Conclusion: CS might recover the balance of Th 1/Th 2 cytokines and enhance Th 1 immune response in patients with CA, and reduced the recurrence of CA.