糖耐量减低患者胰岛素抵抗与血脂的相关性研究

Correlation of blood lipids and insulin resistance in patients with impaired glucose tolerance

分析220例2型糖尿病患者的一级亲属中糖耐量减低（IGT）者胰岛素抵抗（IR）对血脂的影响，并与正常糖耐量（NGT）组相比较。结果，IGT组（120例）血清TG、TC、LDL—C水平较NGT组升高，HDL—C降低，且稳态模型胰岛素抵抗指数（HOMA—IR）、胰岛素曲线下面积（胰岛素AUC）也升高（均P〈0．05）；IGT患者血清TG水平与HOMA—IR及胰岛素AUC正相关，HDL—C与HOMA—IR负相关（P〈0．05）。因此，IGT患者已存在血脂异常，且和IR密切相关。

Blood lipid level and its associations with insulin resistance were studied in patients with impaired glucose tolerance （IGT）. Two hundred and twenty first degree relatives of type 2 diabetes mellitus were grouped into normal glucose tolerance （ NGT ） and IGT groups according to results of oral glucose tolerance test. Compared with the NGT group, the IGT patients had higher serum levels of total triglyeeride （ TG）, total cholesterol （ TC ）, low density lipoprotein-C （ LDL-C ） but a lower serum level of high density lipoprotein-C （HDL-C）. Homeostasis model of assessment for insulin resistance index （HOMA-IR） and area under curve of insulin （AUCI） also increased. A positive relationship was found between TG and HOMA-IR （or AUCI）, but a negative relationship existed between HDL-C and HOMA-IR. In conclusion, abnormal blood lipid metabolism is present in IGT patients and it has a close correlation with insulin resistance.