摘要
[目的 ]研究乳糜尿现症病人和非现症病人的外周血 T-淋巴细胞亚群 (CD3+ 、 CD4+ 和 CD8+ )的变化。[方法 ]采用 SAP法检测待检人群的外周血 T-淋巴细胞亚群。 [结果 ]现症病人的 CD3+、CD4+比非现症病人及健康人对照组显著减少 ,CD8+ 显著升高 ,CD4+ / CD8+ 明显降低 (P<0 .0 0 1) ,而且 CD4+ / CD8+ 的减低与乳糜蛋白尿的轻重程度呈正相关。非现症病人与健康人对照组 CD3+ 、 CD4+ 、 CD8+ 及 CD4+ / CD8+ 均在正常范围 ,无显著差异。 [结论 ]丝虫性乳糜尿患者机体免疫系统的比例失衡 ,免疫调节机能出现异常 ,且呈抑制趋势。
Objective] To study the changes in T\|lymphocyte subsets CD4\++:CD8\++ of peripheral blood in 29 patients with present chyluria(PPC), 29 patients with chyluria history but without chyluria (PNPC) and 38 healthy controls. [Methods] The determination of CD3\++, CD4\++ and CD8\++ was conducted using test reagents kits. [Results] The percentage of CD3\++, CD4\++ cell were signfcantly decreased in PPS group than in PNPC and healthy control group,the ratio of CD4\++/CD8\++ being under 1\^0.The T\|lymphocyte subsets (CD3\++, CD4\++, CD8\++) and CD4\++/CD8\++ ratio of both PNPC and healthy control group were all within normal range. [Conclusion] The immune function of the patients with filarial chyluria was impaired in terms of the changes in T\|lymphocyte subsets.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
2000年第2期103-105,共3页
Chinese Journal of Parasitology and Parasitic Diseases
