青蒿琥酯对防汛人群预防日本血吸虫感染的效果

THE EFFECT OF ARTESUNATE IN PREVENTING THE POPULATIONS FROM SCHISTOSOMA JAPONICUM INFECTION DURING FLOOD-CONTROL

[目的 ]评价大规模应用青蒿琥酯预防性治疗接触疫水的人群预防血吸虫感染的效果。 [方法 ]在防汛中对 170 31人在接触疫水后第 7天开始口服青蒿琥酯 ,每周 1次 ,每次 30 0 m g,连服 3wk,记录副反应。距末次服药平均 17d后开始查病 ,部分于两个月后随访。 [结果 ]全组无急性血吸虫病发生 ,EL ISA阳性 2 0 4例 (1.2 0 % ) ,COPT>3%者 195例 (1.14% ) ,仅数例有肝功能变化。服药副反应发生率低 ,绝大多数不需特殊处理。 [结论 ]青蒿琥酯预防血吸虫病具有高效、安全及方便等优点 ,是目前比较理想的预防药 ,可推广使用。

Objective] To evaluate the prophylactic effect of artesunate in high\|risk populations who had contacted the infested water.[Methods] From the 7th day post\|exposure to infested water, a total of 17 031 people who had contacted the infested water for more than 20 days had been treated with artesunate at a dose of 300 mg once a week for three successive weeks. On day 17 after the last medication, they were examined for schistosomiasis and followed\|up 60 days later. [Results] No acute schistosomiasis case was found. ELISA\|positive was found in 204(1\^20%) and COPT>3% was found in 195 cases (1\^14%). The side\|effects were slight. [Conclusion] Artesunate is highly effective and safe for the prevention of schistosomiasis.\;