摘要
目的观察溃结灵方治疗溃疡性结肠炎(UC)患者的临床效果及作用机制。方法将80例UC患者随机分为治疗组和对照组各40例,治疗组给予溃结灵方每日1剂和柳氮磺吡啶片每次1.0g,每日2次,对照组仅给予柳氮磺吡啶片,两组均8周为1个疗程。观察两组患者的临床疗效,治疗前后检测DNA酶Ⅰ、Fascin蛋白的表达。结果治疗组临床有效率(92.5%)高于对照组(72.5%),差异有统计学意义(P<0.05);治疗组患者治疗前后DNA酶Ⅰ分别为(109.73±28.46)、(135.13±36.10)μg/L,对照组治疗前后分别为(106.50±27.54)、(120.03±27.72)μg/L,两组治疗后均较治疗前明显提高(P<0.05或P<0.01),治疗后组间比较差异亦有统计学意义(P<0.05);治疗组Fascin蛋白转阴性率为86.49%,对照组为66.67%,治疗组显著高于对照组(P<0.05)。结论溃结灵治疗UC疗效确切,并能明显提高UC患者DNA酶Ⅰ活性,使Fascin蛋白表达转阴。
Objective To observe the therapeutic effect and mechanism of Kuijieling（TCM formula for ulcerative colitis）on ulcerative colitis（UC）.Methods Eighty cases of UC were randomized into treatment group and control group,with 40 in each.The treatment group was given one dose of Kuijieling decoction daily and 1.0g of Sulfasalazine tablets each time,twice daily.The control group was given Sulfasalazine tablets.Both groups were treated for 8 weeks as one treatment course.The therapeutic effect was observed and the expression of DNA enzyme 1 and Fascin protein was detected before and after treatment.Results The total effective rate of the treatment group and control group was 92.5% and 72.5% respectively,with significant difference between groups（P0.05）.The expression of DNA enzyme 1 was（109.73±28.46）μg/L and（135.13± 36.10）μg/L before and after treatment respectively in the treatment group.The expression of DNA enzyme 1 was（106.50± 27.54）μg/L and（120.03±7.72）μg/L before and after treatment respectively in the control group.Both groups were significantly increased in the expression of DNA enzyme 1 after treatment（P0.05or P0.01）,especially in the treatment group （P0.05）.The negative rate of Fascin protein in the treatment group and control group was 86.49% and 66.67% respectively,with significant difference between groups（P0.05）.Conclusion Kuijieling is effective for UC,which can obviously improve the activity of DNA enzyme 1 and make Fascin protein negative.
出处
《中医杂志》
CSCD
北大核心
2013年第1期45-47,共3页
Journal of Traditional Chinese Medicine
基金
2011年度苏州市中西医结合科研基金资助项目(SYSD2011159)
