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少突胶质细胞的钙信号

Calcium signaling in oligodendrocytes
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摘要 钙是细胞内重要的第二信使。参与机体内多种生理过程，其胞内的钙信号传递依赖于胞内外的钙离子（Ca^2＋）浓度差，表现为胞质内钙的变化。Ca^2＋进入细胞内与钙的受体如钙调素（calmodulin，CaM）结合后发挥系列效应。以往认为Ca^2＋仅在兴奋性细胞中起传递信号作用．但近年来随着研究的深入，发现无论是兴奋性还是非兴奋性细胞，钙都作为第二信使参与信号转导及基因的表达调控。少突胶质细胞是中枢神经系统髓鞘形成细胞，被认为是中枢神经系统中一种非兴奋性细胞．其对于细胞外的刺激可表现为胞内钙浓度的变化从而调控细胞活动。
作者 王凌云 肖岚
机构地区 第三军医大学基础部组织学与胚胎学教研室 辽宁省葫芦岛市第九二九四一部队
出处 《中华神经医学杂志》 CAS CSCD 北大核心 2013年第1期93-95,共3页 Chinese Journal of Neuromedicine
基金 国家自然科学基金（31171046） 重庆市自然科学基金（CSTC2011BA5006）
关键词 钙信号 钙稳态 少突胶质细胞 Calcium signaling Calcium homeostasis Oligodendrocyte
分类号 R329 [医药卫生—人体解剖和组织胚胎学]
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参考文献24

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中华神经医学杂志
2013年 第1期

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