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白细胞介素-17在强直性脊柱炎炎症形成中的作用

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摘要 强直性脊柱炎（ankylosing spondylitis，AS）是一种以骶髂关节和脊柱关节韧带、肌腱附着点炎为主要症状的慢性炎性疾病。患者临床主要表现为腰、背、颈、臀、髋部疼痛以及关节肿痛，严重者可发生脊柱畸形和关节强直，约42％的患者还伴有一处或多处眼、消化道、皮肤、心血管、肾脏及肺脏并发症。该病病因未明，目前已证实其发病和人类白细胞抗原（HLA）．B27基因密切相关，并有明显家族聚集倾向.
作者 杨钦 徐卫东
机构地区 第二军医大学附属长海医院骨关节外科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2013年第1期55-57,共3页 Chinese Journal of Rheumatology
基金 上海科学技术委员会科研项目计划（10JC147900）
关键词 强直性脊柱炎 白细胞介素-17 人类白细胞抗原 炎症 肺脏并发症 B27基因 关节韧带 骶髂关节
分类号 R593.23 [医药卫生—内科学]
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参考文献24

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二级参考文献139

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  • 9Weaver CT, Hatton RD, Mangan PR, et al. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Ann Rev Immunol, 2007, 25: 821-852.
  • 10Deshpande P, King IL, Segal BM. Cutting edge: CNS CD11c^+ cells from mice with encephalomyelitis polarize Th17 cells and support CD25^+CD4^+ T cell-mediated immunosuppression, suggesting dual roles in the disease process. J Immunol, 2007, 178: 6695-6699.

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中华风湿病学杂志
2013年 第1期

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